Plum pox virus (PPV) was discovered for the first time in North America in 1999 in a peach orchard in Adams County, Pennsylvania. In Pennsylvania, peach, plum, nectarine, and apricot stone fruit and native and ornamental Prunus are susceptible to PPV, Strain D. Pennsylvania was declared free of the virus in October 2009 after three years of negative testing. Formal orchard surveys for the virus are no longer occurring, though standard testing of nursery material continues. Additional orchard monitoring may be proposed in future years, as part of ongoing early detection strategies for pests of concern. Lifting of the quarantine in Pennsylvania opened many acres for replanting Prunus. However, growers need to remain vigilant for any early indications the virus has returned. New plantings offer the opportunity for a “fresh start” and growers must plan carefully to get the most from their investment.